⒊Gene transduction

In gene therapy and generation of transgenic animals, development of cell type-specific and/or sequence-specific gene transfer have been highly desired as a new procedure for gene delivery.

We have attempted to engineer viral vectors with a modified envelop to improve specificity for gene delivery, and we have also attempted to develop site-specific recombination and integration of transgene. Moreover, in order to enhance the productivity of recombinant proteins, we have developed a gene amplification procedure into chromosome of target cells.